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KMID : 0606920140220060503
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Biomolecules & Therapeutics
2014 Volume.22 No. 6 p.503 ~ p.509
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Paraquat Induces Apoptosis through Cytochrome C Release and ERK Activation
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Seo Hong-Joo
Choi Sang-Joon
Lee Jung-Hee
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Abstract
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Paraquat has been suggested to induce apoptosis by generation of reactive oxygen species (ROS). However, little is known about the mechanism of paraquat-induced apoptosis. Here, we demonstrate that extracellular signal-regulated protein kinase (ERK) is required for paraquat-induced apoptosis in NIH3T3 cells. Paraquat treatment resulted in activation of ERK, and U0126, inhibitors of the MEK/ERK signaling pathway, prevented apoptosis. Moreover, paraquat-induced apoptosis was associated with cytochrome C release, which could be prevented by treatment with the MEK inhibitors. Taken together, our findings suggest that ERK activation plays an active role in mediating paraquat-induced apoptosis of NIH3T3 cells.
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KEYWORD
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Paraquat, NIH3T3 cells, ERK1/2, Apoptosis, Cytochrome C, MAPK
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